With Randomail, you can create hundreds of e-mails. Create a new alias when you sign-up on a website. There is a Google Chrome extension for that. It prevent you from identity leaks and it works perfect with Lastpass or 1Password.
When you receive a new e-mail on a Randomail alias, this e-mail is forwarded to your real mailbox (Gmail, Hotmail, etc). You can reply to e-mails using Randomail aliases.
You can manage your own domain name to make aliases like email@example.com. You can use advanced filters, use PGP. You can even automatically forward it to your wife!